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EGF / HGH

EGF


 



What is human EGF (Epidermal Growth Factor)


- EGF is a low-molecular-weight polypeptide with 53-amino acid residues. 

-   EGF participates in regulation of growth, proliferation, differentiation, and survival of skin epithelial cells.  

-   EGF induces epithelial development and promotes angiogenesis during wound healing  process. 

-   In vitro, EGF is a mitogen for fibroblasts, epithelial and endothelial cells.  

-   We manufacture a human EGF equivalent starting from a chemically synthesized DNA using recombinant DNA technology and microbial fermentation. 

-   ED (human EGF equivalent; sh-Oligopeptide-1) in Clairesome-ED is encapsulated in a liposome-based carrier (Clairesome) for protein stability and skin hair follicular delivery.  




hGH 



 

 
What Is hGH (human Growth Hormone)

-   Growth hormone (GH), also known as somatotropin, is a peptide hormone that is synthesized and secreted by the somatotrophs of the anterior pituitary gland.

-   The main action of GH is to stimulate linear growth in children; however, it also fosters a healthy body composition by increasing muscle and reducing fat mass, maintains normal blood glucose levels, and promotes a favorable lipid profile.

-   The major isoform of the human growth hormone is a protein of 191 amino acids and a molecular weight of 22,124 daltons. The structure includes four helices necessary for functional interaction with the GH receptor.

-   GH exerts some of its effects by binding to receptors on target cells, where it activates the MAPK/ERK pathway, GH also stimulates, through the JAK-STAT signaling pathway, the production of insulin-like growth factor 1 (IGF-1, formerly known as somatomedin ), a hormone homologous to proinsulin.

-   We manufacture a human GH equivalent starting from a chemically synthesized DNA using recombinant DNA technology and microbial fermentation. This molecule contained the identical sequence of 191 amino acids found in native pituitary hormone with the addition of a methionine (met-GH) on the N-terminus, initially required to facilitate the biosynthetic process using E. coli.